FOOD NUTRIENTS & RESPONSES

FADS1 FATS / FAT GENE rs174548 Function; Acetylcholine,

rs174537 Function: Arachadonic Acid; GLA conversion

FADS2 Function: conversion of ALA to EPA

VITAMIN E

VITAMIN D VDR

VITAMIN C SLC23A2

ZINC SLC30A8

VITAMIN KVKORC1 

LACTOSE PERSISTANCE LCT

Sodium ACE / AGT

VITAMIN A: Beta-Carotene Conversion BCMO1

IRON

(Genetic Variation: C282Y & H63D ) Hereditary hemochromatosis is a genetic disorder in which there is excessive accumulation of iron in the body, leading to iron overload. In individuals with the disorder, the daily absorption of iron from the intestines is greater than the amount needed to replace losses. Since the normal body cannot increase iron excretion, the absorbed iron accumulates in the body. Individuals who carry the genes for hereditary hemochromatosis may have no symptoms or signs and the disease is treatable if detected early. Severe symptoms and signs of iron overload include sexual dysfunction, heart failure, joint pains, liver cirrhosis, diabetes mellitus, fatigue, and hypermelanotic pigmentation.

GUT FLORA DIVERSITY FUT2

C allele plays a role in the unfavourable formation of fat cells and lipid metabolism as well as the development of type 2 diabetes.  Elimination of all refined carbohydrates and overall reduction in carbohydrate intake is recommended.

 ACE G;G

Reduction of ACE by 150% and 200% for both alleles respectively, which in turn increases the general sensitivity to carbohydrates.  Elimination of all refined carbohydrates and overall reduction in carbohydrate intake is highly recommended.

C allele is associated with higher levels of obesity in the presence of processed, trans and oxidative fats.

APOA2 C;C:

CC genotype demonstrated higher body mass index scores and a higher incidence of obesity, but only if they consumed a diet high in saturated fat.  The C allele is associated with a greater inflammatory response to unhealthy fats.  Elimination of processed/ trans / oxidative fate is highly recommended.

PPARG C;G:

The C allele plays a role in the unfavourable formation of fat cells and lipid metabolism as well as the development of type 2 diabetes.  Reduction of processed/ trans / oxidative fate is highly recommended.

APOC3 A;C:

The C allele is associated with a impaired ability to transport triglycerides from the blood into the cells for use as energy along with obesity ad metabolic syndrome in the presence of excess dietary fats.  Reduction of processed/ trans / oxidative fate is highly recommended.

For weight loss and weight management, FTO AA homozygous may require up to 35% calories from protein. 

For cases where individuals have both high carbohydrate and fat sensitivities, increasing protein to account for energy requirements may be necessary too. Baseline protein intake is around 1.6 protein per 1 Kg ideal healthy body weight