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    • ABOUT ANNA
    • MY MISSION & MY STORY
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  • NUTRITIONAL THERAPY CLINIC
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    • BOOK AN APPOINTMENT
    • HEALTH PACKAGES
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GI Effects Comprehensive Stool Profile

Additional 3.4% Paypal charges apply before test-kit can be dispatched.

Categories: Gastro-Intestinal Tests, General Health, GENOVA, Gut Health & Microbiome, TOP 10 RECOMMENDED PANELS
  • Description

Description

Why Choose Genova Diagnostics’ Gastrointestinal Products?

GI Effects is an innovative stool test measuring premier biomarkers of gastrointestinal function, providing valuable clinical insight into digestive performance, gut inflammation, and the gut microbiome — areas affecting not only GI health, but overall health as well.

  • GI Effects is a comprehensive assessment of complete GI health, assessing the root cause of most gut complaints.
  • Genova uses a combination of PCR, culture, and microscopic methods to ensure any and all relevant organisms are identified.
  • Genova recovers live organisms (yeast and bacteria) for susceptibility testing and improved treatment options.
  • Genova measures metabolomics and can assess the interaction between the microbiome and its host.
  • Genova is the market authority on stool inflammatory markers, testing calprotectin, EPX and sIgA.
  • Genova has amassed a database of hundreds of thousands of complete stool profiles. Our data driven and evidence-based analysis ensures the highest standard of analytical validity and clinical utility.

 


When should the GI Effects Comprehensive Stool Profile be considered?

GI Effects assesses three critical areas of gut health: digestive function, gut inflammation, and the gut microbiome—areas affecting not only GI health, but overall health as well. For patients with symptoms that may have gastrointestinal dysfunction as their root cause, comprehensive stool diagnostics provide an effective tool for gaining clinical insight into next steps.

Assessing and normalizing GI function can have profound effects on overall health, leading to improvement in these and other conditions.

  • Irritable Bowel Syndrome (IBS)
  • Inflammatory Bowel Disease (IBD)
  • Diabetes
  • Obesity
  • Cardiovascular Disease
  • Celiac and Other Malabsorption Disorders
  • Mood Disorders
  • Autoimmune
  • Autism

The GI Effects Comprehensive Stool Profile can reveal important information about the root cause of many common gastrointestinal symptoms such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation. This stool analysis utilises biomarkers such as Calprotectin to differentiate between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).

Gut microbes are codependent with one another and with their human host, and the health of one affects the other. A sizeable volume of research associates a dysbiotic, or imbalanced gut microbiome with multiple disease states both within and outside of the GI tract.1,2 The diverse metabolic activities of the microbiome ultimately impact the human host, and the activities of the human host ultimately affect the health of their microbiome.


The GI Effects Comprehensive Stool Profile Biomarkers

The biomarkers from the GI Effects Comprehensive Profile are reported using the DIG framework, providing key clinical information for three main gastrointestinal functional areas:

Digestion/Absorption:

  • Pancreatic Elastase-1 is a marker of exocrine pancreatic function.
  • Products of Protein Breakdown are markers of undigested protein reaching the colon.
  • Fecal Fat is a marker of fat breakdown and absorption.

Inflammation/Immunology:

  • Calprotectin is a marker of neutrophil-driven inflammation. Produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).3,4
  • Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response.
  • Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.

Gut Microbiome:

  • Metabolic indicators, including short-chain fatty acids and beta-glucuronidase, demonstrate specific and vital metabolic functions performed by the microbiota.
  • Commensal Bacteria demonstrate the composition and relative abundance of gut organisms.
    • More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques.
    • GI Effects assesses a set of 24 genera/species that map to 7 major phyla.
  • Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms.
  • Bacterial and mycology sensitivities are provided for pathogenic or potentially pathogenic organisms that have been cultured. The report includes effective prescriptive and natural agents.
  • Parasitology includes comprehensive testing for all parasites on every parasitology exam ordered.
    • GI Effects provides microscopic fecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
    • 6 Polymerase chain reaction (PCR) targets detect common protozoan parasites including Blastocystis spp. with reflex subtyping 1-9, Cryptosporidium spp., Cyclospora cayetanensis, Dientamoeba fragilis, Entamoeba histolytica, and Giardia. PCR for organisms is emerging as a highly sensitive method for infectious organism detection.
    • Selection of a one-day or three-day sample collection is based on the clinician’s clinical index of suspicion for parasitic infection. If there is no/low suspicion, a one-day sample will likely be adequate. For high suspicion, a three-day sample collection is optimal.

Genova Diagnostics is excited to announce the addition of polymerase chain reaction (PCR) for parasites to the GI Effects Profiles. PCR is a highly sensitive and specific methodology that detects an organism’s DNA.

The GI Effects now includes 6 PCR targets that detect common protozoan parasites:

  • Blastocystis spp. with reflex subtyping 1-9
  • Cryptosporidium spp.
  • Cyclospora cayetanensis
  • Dientamoeba fragilis
  • Entamoeba histolytica
  • Giardia

The 6 PCR targets replace the 3 EIA biomarkers. The GI Effects upgrade also includes several report enhancements for ease of use.


Additional Biomarkers Available:

  • Campylobacter
  • Clostridium difficile
  • Escherichia coli
  • Fecal Lactoferrin
  • Helicobacter pylori
  • Macro Exam for Worms
  • Zonulin Family Peptide
  • KOH Preparation for Yeast

What Advantage Does the Profile Offer Compared to Other Diagnostics?

A structured faecal biomarker panel offers the advantage of assessing multiple functional areas that may be contributing to symptoms. For example, diarrhea could stem from multiple causes including pancreatic exocrine insufficiency, inflammation, food allergies, or the presence of a pathogenic or potentially pathogenic organism. A positive result on one or more faecal biomarker tests may guide therapy, either by suggesting a treatable alternative diagnosis or by eliminating a diagnosis from further consideration. The latter allows individualised targeted treatment to be redirected to more likely diagnoses.5,6

GI Effects® represents the best technical available to assess the gut microbiome, combining:

  • 16S rRNA gene polymerase chain reaction (PCR) amplification technique for anaerobic commensal bacteria
  • Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for bacterial and fungal species identification via culture
  • Gold standard microscopic ova and parasite (O&P) detection
  • Real-time PCR for the identification of 6 common parasites
  • Next-Generation DNA sequencing for Blastocystis spp. with reflex subtyping 1-9

The test report is organised so that the clinician may move through results in a logical order that enhances clinical utility, starting with innovative Interpretation-At-A-Glance pages to synthesise the information.

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