This test combines the Adrenal Stress Profile and Metabolic Analysis Profile tests to provide a comprehensive analysis of various factors that may be implicated in chronic fatigue and other related conditions.
Metabolic Analysis Profile:
The Metabolic Analysis Profile is a nutritional test that assesses urine metabolites in order to evaluate four critical areas of metabolism: gastrointestinal function, cellular and mitochondrial energy production, neurotransmitter processing, and amino acid/organic acid balance as influenced by vitamin/mineral cofactors. Results can be used to address chronic systemic complaints ranging from chronic fatigue and mood disorders to headache, muscular/joint pain, and digestive problems.
The Metabolic Analysis Profile is a nutritional test using an urinary assessment of 46 key organic acids grouped according to their primary roles in the following four central areas of metabolism.
Gastrointestinal Function — This profile measures eight markers that can reveal malabsorption and dysbiosis. These imbalances can be addressed to improve gut health and to help prevent or alleviate: chronic digestive problems, common causes of nutritional deficiency, yeast overgrowth, cognitive impairment, gastrointestinal distress, and degenerative conditions.
Energy Production —This profile assesses metabolites that serve as important intermediates in the citric acid (Krebs) cycle. This cycle supplies the body with its primary energy needs, converting 90% of food energy into cellular energy. This subpanel also includes:
- Carbohydrate metabolites that can signal impaired glucose metabolism
- Markers that help evaluate the breakdown of fats and production of cholesterol
- A marker measuring the production of coenzyme Q10
Imbalances of cellular energy metabolites are linked with chronic fatigue, accelerated cell breakdown, and unhealthy aging.
Neurotransmitter Metabolites – A special grouping of neurotransmitter metabolites serve as important diagnostic indicators of abnormal metabolism that can underline many key aspects of neuropsychiatric function. These markers are urinary metabolites of powerful neurotranmitters that act on the central nervous system, including: Epinephrine, Dopamine, and Serotonin. These substances can profoundly influence patterns of stress response, emotional well-being, cognition, and sleep.
Assessment of Nutrient Sufficiency — This nutritional test provides a functional assessment of nutrient sufficiency and usage that covers a broad range of vitamins, coenzymes, elements, enzyme activators, and other nutrients. An analysis of amino acid metabolites which require vitamin and mineral cofactors for their metabolism can hint at deficiencies of: vitamins B6, B12 and C, magnesium, copper, iron, and various amino acids.
Adrenal Stress Profile:
This saliva test can detect imbalances in the daily circadian secretions of the stress hormones cortisol and DHEA. Imbalances in these hormones can indicate an inappropriate response that can negatively impact energy levels, emotions, and many other health complaints. These include anxiety, chronic inflammatory conditions, allergies, chronic fatigue syndrome, insomnia, depression, migraines, headaches, recurrent infections, menstrual difficulties and infertility.
CortisolIsocitric Acid / 2-Hydroxyphenylacetic Acid / 3-Hydroxyproprionic Acid / a-Ketoisovaleric Acid / b-Ketoglutaric Acid / Citramalic Acid / Indoleacetic Acid / Lactic Acid / Malic Acid / Pyruvic Acid / 3-Methyl-4-OH-phenylglycol / a-Ketoadipic Acid / a-Keto-b-Methylvaleric Acid / Cis-Aconitic Acid / Citric Acid / Homogentisic Acid / Kynurenic Acid / Orotic Acid / Phenylacetic Acid / Suberic Acid / Succinic Acid / Creatinine / 4-Hydroxyphenylpyruvic Acid / 5-OH-Indoleacetic Acid / a-Ketoglutaric Acid / a-Ketoisocaproic Acid / Arabinoseb-OH-Butyric Acid / Formiminoglutamic Acid / Pyroglutamic Acid / Adipic Acid / b-OH-b-Methylglutaric Acid / Dihydroxyphenylpropionic Acid / Fumaric Acid / Glutaric Acid / Homovanillic Acid / Methylmalonic Acid / Tartaric Acid / Vanilmandelic Acid / Adrenal Stress Profile (ASP) / Metabolic Analysis Profile
Turn Around Time: 21 Days
Specimen Requirements: First morning urine collection; two tubes of 5ml each (samples frozen) 4 X plain saliva taken oner 12 hours (Frozen)