Chronic Fatigue Syndrome is a notoriously tricky illness to pin-down.  Since CFS related health-issues tend to be serious to the degree that it can be life altering, but they are usually not so serious that they become a classified disease like heart disease.  This is not only confusing to the sufferer but immensely frustrating too since many of the symptoms are not taken seriously by mainstream medicine.


1.  The first condition to be common among CFS sufferers is Adrenal Fatigue

Unrecognised by most General Practitioners, Adrenal Fatigue affects our energy performance.  It influences how we regulate energy via our adrenal glands, but it is not Addison’s Disease – which is a recognised disease. Adrenal Fatigue is a serious life-altering condition – but it is not Adrenal Failure.

So what tends to happen is the adrenal glands are tested with a blood test.  But because a blood test is not a sensitive enough test to pick up on adrenal dysregulation, results come back suggesting they are functioning normally.

This presents false understanding and confusion when the sufferer is experiencing low energy due to sub-optimal adrenal function, but the tests being used are not sensitive enough to pick up on the true performance.

A four-point saliva test should be provided, obtainable by private labs through the UK and overseas.  The four-point saliva test picks up on steroid hormone excretions throughout the day, tracking adaptogenic responses.  And therefore provides a clear understanding of how the adrenal glands are ‘responding’ and adapting to daily stressors.


2.  The second condition is Left Ventricular Disease

Studies release that a shocking 35% of us is said to have this condition, however, the CFS / ME sufferer will experience the downstream effects of this condition as a chronic and debilitating element of the whole CFS picture.

They may be aware that their heart feels unstable but unable to identify this through medical means since it is not classic heart disease and easily missed.


3.  The third piece to the Chronic Fatigue conundrum is the role of Gut Dysbiosis

Often present in those with Chronic Fatigue.  Gut Dysbiosis fits into the picture of both Adrenal Fatigue and Chronic Fatigue Syndrome due to the role the adrenal glands play in providing an anti-inflammatory corticosteroid (cortisol) to the body to buffer inflammation in the gut.

  • Causative factors for inflammation in the gut 
  • Food Intolerances / Virus / Toxins such as methyl-mercury / Stress

Gut Dysbiosis has a number of potential causative factors with stress, food intolerances as well as toxins such as methyl mercury trumping possible causes for. Gut Dysbiosis is chronic low-grade inflammation, however, it is not inflammatory bowel disease (IBD) and therefore unrecognised by medical communities once again.


4.  The fourth mechanical issue to arise within CFS, and ties in with a performance of the heart, liver and adrenal glands are Mitochondrial dysfunction

This is not an inborn error of the mitochondria, however, it is an inherited epigenetic malfunction.  What that means is that due to the environment the mitochondria has been presented within, the functionality of mitochondria is reduced.  The trouble is, when there is poor mitochondrial function, then everything else in the body is affected.  But in particular, the function of the heart and liver since this is where mot mitochondria reside.

  • Nutrients which positively support Mitochondria Function / Krebs Cycle
  • D-Ribose / L-Carnitine / B3 (NAD) / Co-enzyme A / Co-enzyme Q10

What causes mitochondrial breakdown?

Crisps, rancid fats, hydrogenated oils, poor nutrient profile, toxic metals blocking biochemical pathways and oxidative stress.


5.  The fifth area of health which has more studies relating to CFS than any other area is Nitric Oxide and Oxidative Stress

Within the central nervous system and under normal conditions, Nitric Oxide (NO) is an important physiological signaling molecule, however when produced in large excess Nitric Oxide also displays neurotoxicity and is a risk to heart health.

Nitric Oxide has been found to be excessively high in Chronic Fatigue Sufferers and is seen in conjunction with risk factors for cardiovascular disease.


6.  The sixth element of Chronic Fatigue Syndrome is observable Inflammation

Inflammation is present but it is not a classifiable Auto-immune Disease.


7.  The seventh component of this complex condition is the presence of low-grade infections

Usual infections often present in CFS sufferers

Epstein Bar / HHV6 / Enteroviruses / Cytomegalo viruses / Parovirus B19 / Retrovirus

Co-infections often present in CFS sufferers

Mycoplasma / Chlamydia / Chronic Borrelia / Bucella / Rickettsia / Babesia 

All together we can view this complex condition as a disease of compromised milieu. Triggered by increased cellular stresses such as toxic heavy metals, infections, and emotional stressors.

Strengthening the milieu / biological terrain interior will help to de-activate the viruses present.


8.  Finally, the eighth piece in this Chronic Fatigue quandary is the emotional status of the CFS sufferer

It is interesting to note that Chronic Fatigue patients tend to fall in three main personality categories known as energy depleting psychology types.

  • The Achiever Perfectionis Type
  • Anxiety Type
  • The Helper Type

There can also be a genetic or epigenetic predisposition element to our stress responses to emotional trauma. Meaning that this can be either genetically inherited or genetically learned behaviour.  And then the condition/illness itself perpetuates further trauma in the sufferer as there is a constant fear of becoming ill.  Other behaviours feed into this cycle such as avoidance of certain foods and situations that they believe will make their condition worse.

Each category will be expanded upon within subsequent posts in the coming weeks.

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