We live in a toxic world, and so by default, we would all benefit from routine detoxification.

Within a previous post, I talk about why some people have an increased requirement for routine detoxification; this can be epigenetic; meaning lifestyle or environmentally influenced.   

Epigenetics determines those who require daily or routine detoxification in the form of food and Old Fashioned mechanical detoxification support such as Epsom salt baths, coffee enemas, and castor oil packing. Whilst others tend to get away with a 1-2 week detox programme perhaps 2-4 times a year.

Heavy metals are of a particular issue in the 21st century. Since we are living within an epidemic of heavy metal environmental over-whelm, therefore with my Naturopathic Nutritional hat on personally I choose to view daily detoxification as a way of life.

However, there are two pillars to detoxification. With the second pillar being; nurture.  A lack of nutrients at source (from within our soil) to support and boost our detoxification systems means we should also be paying close attention to supplementing with the appropriate range of nutrients.

These two pillars ‘detoxification and nurture’, complete every home maintenance programme.  With correct nutrients plus regular cleansing, we can keep our self-healing mechanisms strong and clean.

And the good news is, no disease can thrive inside a clean body!


Clean body, clean emotions, clean mind:

  1. Detox each day
  2. Exercise each day
  3. Love your family and laugh each day


Step one

Step one always has to be Clean the Colon. By this, I am referring to the Large Intestine.

Include some cleansing pectins, gums, and clay; modified citrus pectin, psyllium husks, slippery elm, bentonite clay.

Include some antimicrobial supplements; humic acid, grapefruit seed, takuna, berberine, uva ursi.

Clean out any parasites; use wormwood, black walnut.

And physically clean the colon with colonic hydrotherapy 2-4 times a year.

Step two

Clean the urinary tract and kidneys.

My favourite cleansing agents for the kidneys; NRF2 Renew, Clear Away Cofactors, parsley, asparagus, marshmallow root and lots of purified water!

Support your kidneys by taking the stress of ‘homeostasis’, you can think about including ionic minerals in your water, such as E-Lyte.

Step three

Clean the liver.

Our livers are complex workhorses with differing strengths and weaknesses in each of us.  For instance, it is largely down to our livers whether we go grey early or late in life.  Genetically coded from birth, but not scripted. Meaning, we don’t HAVE to go grey, just because the propensity is there.

There is a number of different clearance pathways within our livers, with liver cleansing being the best way to boost over-all function. 10-15% increased productivity comes from cleansing the liver, which I can feel instantly when I get the cleansing right for me.

My all-time number 1 has to be Coffee Enemas.  At they boost the glutathione pathway.  My GST GSP enzyme is non-existent, and the reason why I started to go grey in my early 40’s.

2, has to be Liposomal glutathione

3 Chanca Piedra, keeping my gall-bladder and liver grit-free.

4. Calcium D Glucarate for the glucuronidation pathway, mine seems especially poor.  Poor glucuronidation results in estrogen build-up, which as we all know can contribute to a pre-cancerous picture.

5. Other forms of Sulphur such as MSM, and NAC especially NAC from Biomedica is great.  Selenium also helps as Selenium converts to NAC, along the Glutathione pathway.

6. Malic acid to widen the ducts of the biliary tree, so as long as you are not struggling with candida get those organic apples in daily.

The mini liver cleanse:

Day 1; Liquidise a lemon and lime with a 6 oz cup of water, some ice cubes, 1 Tbsp olive oil, 1 x clove of organic garlic and 1 x chunk of ginger.

Day 2; Liquidise a lemon and lime with a 6 oz cup of water, some ice cubes, 2 Tbsp olive oil, 2 x cloves of organic garlic and 2 x chunks of ginger.

Day 3; Liquidise a lemon and lime with a 6 oz cup of water, some ice cubes, 3 Tbsp olive oil, 3 x cloves of organic garlic and 3 x chunks of ginger.

Adding into this cleansing start to the day, you can include beetroot, carrots, lemon, and avocado to your lunch for further cleansing.  Although all vegetables will support your liver to go for a broad spectrum of colour rather than mono selective.

Step four

Clean the lymphatic system:

Foremost, stay hydrated and include electrolytes in your water.

Once we have fluid in the system we can then manipulate it with any of the following:

  • Daily skin brushing
  • Daily rebounding on a trampette
  • Daily or weekly hot and cold showers.

When deep cleansing needs to be supported then consider once a week Peat Mud Baths, and the herbal blend Essiac discovered and formulated by Caisse.

The 7 toxicity challenges

After all this your system should have a reduced burden of 7 toxicity challenges:

  1. Systemic; heavy metals or pesticides
  2. Persistent organic pollutants such as xeno-estrogens
  3. Opportunistic viruses
  4. EMF’s such as Magnetic and radiation
  5. Emotional and psychological stressors may surface but also dissipate with detoxification.
  6. Your food choices will be cleaner.
  7. Lastly, take time to nourish yourself spiritually by centering yourself daily.

So when it comes to health and healing there is no such thing as ‘Static’ in your Wellness Programme.  We are either actively getting better or progressively getting worse.

There are of course by-products produced as a result of the work we do on our bodies.  Cleansing can be intensive and demanding.  Detoxification also produces internal toxins. 

One way for the body to shake of toxin load and anti-body bi-products is for our immune systems to push us into a fever. This sense of being ‘unwell’ is also known as the Herxheimer effect.  This fever is your body’s attempt to shake off toxins and kick-start the immune system.

Supporting your immune system through detox

We can take immune supportive supplements to enhance immunological support during these challenging time, or as part of a long term maintenance programme.

Some of my favourite immunological compounds

  • Beta-glucans from mushrooms Reishi, Cordyceps; Shitakii
  • Laktoferrin, ImmunoGG

Support oxidative stress during detox

Oxidative stress can be damaging to our genes as it has the power to ‘switch them on and off’.  Some people are genetically predisposed to oxidative stress more than others therefore during a detox it is wise to take additional precautions.

Some of my favourite anti-oxidant protective supplements

  • Tocomin
  • NRF2 Renew
  • Green tea
  • Astaxanthin
  • Melatonin
  • 85% dark chocolate

Protecting the NRF2 pathway with; chocolate, green tea, turmeric is taken with black pepper, resveratrol, berries, grapes, red wine, sulphuraphane, cruciferous vegetables.  This all supports the ARE response, which in turn protects the whole genome.

Flooding the body with Light!

We don’t really know the full benefits of light.  With so much scaremongering around the toxicity effects of light with free radical damage, we ignore the innate healing light can bring in to our cells.

For me, this is one further component when it comes to detoxification. 

Attracting Light into our bodies in the form of light enhancing superfoods is highly recommended.  So how do we invite light into our cells?

Green foods have a way of bringing light into the body since it is captured sunlight with the leafy green anatomy of the plant.  Chlorophyll is said to be the same molecular structure as hemoglobin, with the exception of the magnesium molecule at the centre, rather than iron at the centre. The chlorophyll then travels to our mitochondria in the form of ‘captured sunlight energy’, photo-energising the Krebs cycle, also keeping oxidative stress down.  

However, my favourite method for inviting Light into our bodies has to be via the Budwig Diet! 

Having discovered the pioneering work of Joanna Budwig 15 years ago I have continued to use her valuable recipe within my own health regime, as well as recommending it for many clients. 

Joanna Budwig discovered that by blending Flax Oil with Quark (or you can use Greek yogurt or cottage cheese), the sulphur bond from within quark blends extremely well with the oil.  Creating a complete food for our bodies to recognise, and a vehicle to integrate the oil into our cellular membrane. 

Without this vital sulphur bond, flax oil when ingested can wreak havoc. Since it is a highly volatile oil prone to rancidity, and therefore readily initiates a free radical cascade.

Think about how flax oil is added to paint to create a ‘quick drying’ effect. 

This is entirely due to the highly volatile nature of flax, and how it invites oxygen into itself.  Beneficial for drying paint quickly! And, when integrated correctly this higher influx of oxygen can be beneficial to our cells too.  

But, when we manufacture the oil, we separate the oil from the protein.  And it is within the protein that we find the sulphur component.  Once the oil has been separated from its protein counter-part, the oil is no longer able to be made useful within the body.

Therefore, by blending flax oil with the Greek yoghurt or Quark this completes the sulphur bond and the oil becomes once again useful. 

The second piece to this is when the oil has been properly integrated into our cellular membrane. 

Due to the high number of double carbon bonds existing within the structure of the flax oil we now have the perfect vehicle to invite in Light to the trillions of cellular membranes within us. 

The lock and key of this being that surrounding the double carbon bonds within the fatty acid chain gather electron clouds.  And lots of them! Electrons then attract protons. Protons being sunlight. We, therefore, invite a huge influx of Light (protons) into our bodies when consuming the Budwig  Flax cream. 

Joanna Budwig was in no doubt a pioneer, with her knowledge, wisdom, and message ultimately suppressed by the slimming industry in the 1940s.  Slimming World had it’s agenda, in alliance with the margarine companies at this time, the message was fixated on Margarine being the ultimate slimming fat! However, this is not what the science tells us since corrupt fats corrupt cellular membrane by diametrically opposing the fluid nature of our cell’s membrane. This inadvertently clogs up the receptor sites for healthy fats too, blocking the use of healthy fats.

When double carbons are corrupted by high heat they change formation and are never able to revert back to their original healthy formations.  The corrupt formation then exists in place of the healthy formation within the cellular membrane. Further blocking mineral passage whilst trapping heavy metals within our cells.

The damage from eating margarine and heat treated volatile oils is no less than immense. Rule of thumb; any oil that should be liquid at room temperature should remain liquid when is your body.  Otherwise, you are literally jamming up your cell membrane with something that should not be there.   

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As a nutritionist, we are privileged to work with a variety of client cases. Variety brings comparison. And with that, an informed understanding over time, that by applying the same protocol to the same condition in different individuals, we do not bring about the same results.

The question then has to be asked, Why?

When I first began to ask this question I discovered environmental toxins such as heavy metals, glycophosphates, herbicides, pesticides all from varied and multiple sources. The air we breathe, the water we drink, the food we eat can all be a source of contamination.

Then, some years later I came across the importance of viruses.  How viruses implicate auto-immune conditions and therefore obstruct healing as they change the relation our first line of defense has with our biological systems.

More recently I discovered another layer, parasites.  For the sake of not repeating you can link to my previous post on the three shields here.

However, all of these areas of health are concerning. especially when complex health conditions have manifested.  And are NOT shifting!

So the question is Why?

I am one to never settle for the patient who doesn’t get better.  I believe nothing is random…

Genetic predisposition lies within the differences between how biological systems respond to heavy metals, parasites, and infections.  All of it is valid, each part potentiating the final genetic expression and therefore health outcome.

Let’s start with, what genes do

Simply put, they follow orders.  Meaning that the information we deliver to the gene (in the form of our thoughts, dietary choices, breathing patterns, sleep patterns, etc) is then taken and they then make it happen.  Genes simply inadvertently do what we ask them to do, therefore it’s up to us to put in good orders.

Putting in orders

Putting in the orders comes in the form of ‘how we are and what choices we make’.

When we are calm, cool and collected, our genes will have more nutrients available to complete the usual tasks. The result might be that we convert serotonin to melatonin and then we sleep better, or at least promptly when the lights go out.

We are frazzled and anxious, we rattle through magnesium using it up more rapidly, inhibiting the conversion of methionine to SamE and therefore without the donor SamE Serotonin cannot be converted to melatonin and we do not sleep as well.  This is just one example.

One of the other task genes have to do is that they make enzymes.  Which in turn get rid of things like environmental pollutants such as Bisphenol A, a carcinogen.

The more demand of our genes, in terms of resources the more our genes are tied up, pre-occupied dealing with these additional challenges. And therefore the less able our genes are able to deal with their original roles.  Such as converting serotonin to melatonin.  Or converting toxic substances such as homocysteine to the powerful antioxidant glutathione.

Homocysteine is just one by-product of a normal biological function. Therefore it is a normal toxicity compound produced by the body under completely normal circumstances.

The same gene responsible for lowering homocysteine is also used for clearing the heavy metals Lead and  Thallium from the intestines.

Conversely, the more we give our genes a break, the more they can restore themselves.

Eating junk food or poor quality foods, going to be late all places additional challenges on your genes.  So within the mind, we can know our genetic predispositions, in terms of the outcome of our SNP’s are fluid and malleable rather than fixed.

Factors within the environment which influence our genetic outcome are environmental toxins  They are everywhere and unavoidable to an extent.  The choices we make either increase this challenge or lessen it. But the fact remains none of us are immune to the exposure of heavy metals and environmental pollutants.

And heavy metals are so heavy that they really do put pressure on the genes giving them much extra work, thus slowing them down.

An apt example of this has been provided by Ben Lynch; he says that it is like when you are at a restaurant and order a meal.  But then you don’t get the meal because the chef is so busy putting a fire out in the kitchen.  He says that heavy metals and environmental pollutants are like the fire in the kitchen.  Our genes can’t do their usual work because they are so busy dealing with heavy metals AKA putting the fire out.  The gene no longer cares about lowering homocysteine because they are so caught up in dealing with the additional exposure to pollutants.

We have 19,000 genes in the human body give or take.  With 1000’s known to be impacted directly by heavy metals.  The consensus in current thinking is that ALL of them are influenced indirectly.

Other examples of what happens when our genes are compromised: Hydrogen peroxide is produced by stress, a pro-oxidant, required by our body in order to engage the immune system.  It’s a positive thing, but too much of it turns our hair white.  Our GST glutathione genes deal with this.  However iron, copper mercury, selenium, and zinc also slow it down.  Any gene that is functioning too fast, or too slowly is not a good thing.

Soux, a gene relevant to sulphites is affected by arsenic and tungsten.  Sulphur sensitivity is on the increase, and the question has to be, why?  Few people are aware that cysteine bonds are typically very reactive.  If the body is not breaking it down quickly then we can have too much sulphur and feel BAD!  Increased sulphur sensitivity can result just from chronic inflammation experienced for any of the following reasons; not sleeping well, fighting infections, having lots of heavy metals in the bod.  Cysteine then becomes cystine, but is damaging to all the systems of the body.

MTR, also relevant to methylation is slowed by lead, cadmium, and aluminium, inhibiting the cycling of B12 and therefore homocysteine.

Arsenic, found in apples, chicken, rice and many other foods slow down our body’s ability to produce ATP and therefore promotes mitochondrial dysfunction.

Pon1 is super significant too, as the challenge with glyphosates, barium, mercury, cobalt are all on the rise, slowing this gene down.

And of course, there are cascades … eNos gene is always going to be dirtied by PEMT, MTHFR, and a few others. Methionine synthase is slowed by a lot of common heavy metals, but then COMT is dirtied and so is MAOA.  GSTM1 is always affected and dirtied when any other gene is struggling.

The key here is to draw a road map with multiple SNP’s.  Understanding the wider pictures will give you the advantage. And then, when you learn your genetic road map and can see that you are in the clear WITHOUT SNP’s in certain areas of health, remember that your genes can STILL ACT as if there are SNPs present when genes are presented with the wrong environment. This is due to either a lack of co-factors and/or the presence of heavy metals.  So go by how you feel. Not just gene results!

Action steps

  • Look at your history in detail.  Think about where you have lived. Think about pollution, old lead piping.  Then take action to reduce the burdens.  Find the sources, then reduce or remove them.  Look to your air, environment, food, cosmetics, and water first. The fact of the matter remains if you don’t reduce or remove the current heavy metal burden your load will not be reduced.  And there will always be more.

Functional Medicine Tests to consider

Other effective methods for daily detox

Read about how heavy metals can interfere with the glymphatic system and sleep

Read about the links between heavy metals, parasites, and other organisms

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This month I would like to bring the fabulous DUTCH test into focus. acronym for; Dry Urine Test For Comprehensive Hormones

If you think you have issues with chronic stress, that is affecting your hormones then this is the test for you to complete.  Like most private LAB tests it can be done in the privacy of your home, taking only minutes to complete.




The definition of STRESS is the down-regulation of the HPA axis. Down-regulating the para-sympathetic nervous system, creating a dominant sympathetic response.

What happens when we get stressed? We release cortisol, taking 10 minutes to release, but then between 1-2 hour to break down.  This can vary however depending on the health of the individual since the liver is involved within the process of breaking down cortisol when liver issues are present it can take 3-4 hours or even all day to break down.

Cortisol is then affected by the balance of all other hormones in your body. The Dutch test is a highly sensitive test, bringing all hormones into focus when considering your stress hormones.  See the sample report above.

Cortisol is bound up by cortisol binding globulin transcortin.  Transcortin is very sensitive to estrogen.  Actually, all binding globulins are sensitive to estrogen.  Therefore, when a woman is on the contraceptive Pill, or has been on the Pill for some time, there is a very good chance she is low in FREE cortisol, simply because it is all bound up to the binding globulins.

Free cortisol is less than 5% circulating but in its active form.



  • DHEA, 80% is made in the adrenal glands 20% in the ovaries.
  • DHEAs is what is measured, however, this is not the active form.  DHEA needs to un-S taking the S off to become the active form. This conversation is dependent on the SULT1A1 gene, therefore sulphonation plays a role.
  • DHEA is your master hormone, breaking down to the three estrogens.
  • If you’ve had your 23&Me interpreted, you can check to see the status of your SULT genes.
  • DHEA made in the brain protects the hippocampus from cortisol, therefore DHEA in the brain is a good thing.
  • Stress damages our hippocampus, affecting our short term memory, not good!


When we get too much free cortisol roaming the system, our receptor sensitivity stopping being so active. Adrenaline and cortisol end up circulating.  In this way, chronic stress leads us into a rut, in which the wiring of our neural networks keeps us repeating the same dysfunctional behaviour.  Yet hoping for a different outcome! This by definition, is a form of insanity.

Adrenal Medulla

Other genes which are relevant to our stress response, mood and thinking are the COMT and MAOA. When these are running slow, you will not be breaking down catecholamines easily, and therefore do not break adrenaline down easily either. Check these genes if you are feeling stressed all day! Running slow means a high amount of neurotransmitters are stored since you are not going to break down adrenaline or nora-adrenaline.  Rather, it can carry on ALL day.  Stressy, buzzy, tense.

All there needs to be present to impact this system significantly is an infection, inflammation, food intolerance or a pile of housework building up to tip someone with slow genes to be tipped into overwhelm.

Cerebral cortex > CRH > anterior pituitary > ACTH > cortisol release > adrenaline and noradrenaline.

Our protective, survival mechanism is to shut down the parasympathetic nervous system and upregulate the sympathetic, now we are chronically in fight and flight! At this stage, we are likely to get receptor sensitivity. We can liken this to ‘annoying kid syndrome’ which I use to call being ‘mummed’.  Mum, mum, mum .. for hours.  We then get hyper-sensitive, and cortisol goes up even further because we are not tolerating it.

On the other hand, if you are a super laid back person your COMT and/or MAOA may be running too quickly.  Feed the furnace with additional protein plus Tyrosine.

How do we break the cycle? 

Change the biochemistry through food and nutrient therapy and then also rewire your habits.

Two analogies work for me here:  First, we need to dry up the riverbeds were ‘too much’ of a hormone/catecholamine/ transmitter has been allowed to flood the system. Secondly, it takes a while for a worn-down path to grow grass again, was ‘not enough’ of the right hormone/catecholamine/transmitter has been present.

Stress and Fasting

Clients like to bring in the option of fasting, believing that fasting will help to clear the system and take the stress of the system.  Whilst this is true in cases where adrenal fatigue is NOT present, it is not true for those who do not have a robust HPA axis. Primarily cortisol manages blood sugar levels. Do not stress the system out even more by Fasting when adrenal dysregulation is present.


Cortisol is higher in the morning with the sun. When cortisol is high it suppresses melatonin and growth hormone production.  Cortisol helps to fight infection via inflammation, think viruses, bacteria, etc.  The pro-inflammatory cytokines stimulate the stress system releasing cortisol.

There is real importance in this morning cortisol spike.  When auto-immune symptoms are presented then understanding your cortisol patterns is super important.  Low cortisol in the morning means that the auto-immune regulator does not happen.  Morning cortisol triggers those cells in the thymus who failed central tolerance to get destroyed.  What that means is, before immune cells get let out into the body, the thymus checks whether immune cells are auto-immune.  If cells are auto-immune, then the thymus pushes the cells off to the side and the thymes kill those cells.  Without the morning spike THIS DOES NOT HAPPEN!, and auto-immune cells get let out into the system.

Therefore, if we are consuming foods which create a cortisol spike at night, or we are fighting infection at night, this suppresses melatonin, which in turn stops us from sleeping.  Leads to a low cortisol spike in the morning with auto-immune flare-ups.  For this reason, gluten and HHV6 will play more than one roll in creating auto-immune flare-ups.


When is it best time to test?

  • 5-7 days after ovulation on days 19, 20, 21
  • If your cycles are long, then shift up. If your cycles are short, then shift down.
  • First, track your ovulation through temperature gauging or other symptoms.  Then count forward by 5-7 days and collect your urine.

Look at your Estrogens

Dutch tests for Estrogens E1 E2 E3, which then go through the liver and get converted to Hydroxy 2, Hydroxy 4 or Hydroxy 16.

Each esterogen dominant pathway has key characteristics. Estrogen 4 hydroxy for instance goes down the quinone pathway, correcting to estrogen-related cancers.

16 Hydroxy, the 2/16 ratio 2:16 can implicate estrogen proliferative symptoms such as moody, PMS, tender breasts and weight gain.

2 Hydroxy is The Happy Healthy Way.

Estrogen in the right amount

Good for > bone health

Good for > brain cognition

Good for > temperature regulation

Good for > collagen, tissue skin

Good for > fertility

When it’s decreased, we can face menopausal symptoms, skipping of cycles, low cholesterol even anorexia!

Too much estrogen, pre-disposed from either being on the contraceptive pill, environmental estrogens such as cling wrap, tap water (re-cycling of the hormone pill within the water system:

We can experience being over-weight, diabetes, increased risk of Alzheimer, PCOS.

Reduced hormones, on the other hand, can be a direct result from cholesterol-reducing medication for instance. People seem to over-look that cholesterol makes up all our hormones.  When we lower cholesterol we also lower our testosterone, DHEA and Estrogens.

Other estrogen lowering activities

  • Extreme exercise, marathon running, cross fit.
  • Frequent flying
  • Under appropriate body weight.
  • Head injuries.
  • Surgery decreases the blood flow to the area as capillaries are damaged.
  • Sugar, gums up the works, diabetes, and smoking.
  • Birth control pill reduces estrogen in the long term.

Consider Progesterone

Progesterone helps with anxiety and insomnia as well as the lining of the uterus, as women losing progesterone report anxiety and insomnia.

Alpha-pregnanediol goes down, usually goes up to GABA, supporting the glymphatic system during sleep.

A-pregnanediol typically converts into neuro-steroid ALLO, that crosses BBB (blood brain barrier) and can activate GABA a-receptors.

Progesterone in the brain is calming, supporting neurons, and is even used after traumatic brain surgery or after Stroke.

Progesterone enhances serotonin receptors in the brain and reduces gall bladder activity. Conversely, higher estrogen increases the risk of gall bladder disease and stones.

Those on lots of NSAIDS will typically have low progesterone activity when used for more than 10 days.

Consider Androgens

DHEA: facial hair, acne

Consider FREE cortisol, verses stored cortisol

  • Consider infections
  • Consider allergies
  • Consider food intolerances
  • Consider weight gain

Marker 8-hydroxy-2-deoguanosine (8OHdG)

Marker correlating to chronic inflammation, high stress, high cortisol, insomnia, hypertension, kidney disease, IBD, depression.

What do we do now with this information?

Note where on the dials we are, which is dominant. Are we triple estrogen dominant?

Depending on where your markers are, we may wish to support Phase 1 liver with P450 enzymes and DIM. Or Phase 2 Liver with SamE precursor or SamE if you wish to order it in from the US.  P%P, Mg, Choline, Methionine, Methyl groups TMG are all useful here.

Foods can be influential, but ONLY if stomach acid is good.  This will not be the case where P5P and/or TMG is warranted. Kale, broccoli, Brussel Sprouts, Broccoli Sprouts, artichoke, onions, foods high in FOS and fiber.

Support Glymphatic system for catecholamine clearance at night.

Support MAOA with SamE donations and methyl donors.

Support COMT with Mg chloride.

Support the serotonin pathway.

Support the dopamine pathway.

Harness the benefits of apoptogenic herbs.

Combat infections.

Temper exercise according to the dominant hormone, verses hormone insufficiency.

Support HPA axis with key nutrients; C, B5, Zn, Fe, Mg, Sel

Weight management.

Given the results of your DUTCH test, there are plentiful options to improve your health.  So, if you are interested in ordering this test with result interpretation you can email Anna directly.

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